LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.

Cardiovascular Testing

Most U.S women don’t know their personal risk of heart disease. High cholesterol, diabetes and obesity can all lead to heart disease and stroke. Six in ten women are unaware of their cholesterol numbers, blood sugar levels or body mass index. Heart disease ranked third as the greatest health problem facing U.S. women, with mental health No. 1 and cancer No. 2.1

American College of Cardiology and the American Heart Association guideline recommendations2,3 include:

  • Estimate 10-year risk for atherosclerotic cardiovascular disease (ASCVD)2
  • Due to inherent limitations of risk estimation tools in individual patients, consider the risk-enhancing factors below, which align with those set forth in the 2019 ACC/ACOG Advisory, for adults 40 to 75 years with borderline- (5% to < 7.5%) or intermediate- (≥ 7.5% to < 20%) risk2
    • History of premature menopause (< 40 years) and history of pregnancy-associated conditions that increase later risk, including:2,3
      • Pre-eclampsia
      • Eclampsia
      • Gestational hypertension
      • Gestational diabetes
      • Pre-term delivery
      • Low birthweight for gestational age
      • Polycystic ovary disease
      • Functional hypothalamic amenorrhea
    • Reproductive hormones including oral contraceptives and hormone replacement3
    • Breast cancer3
    • Chronic inflammatory conditions such as rheumatoid arthritis, lupus, and scleroderma2
  • Family history of premature ASCVD (< 65 years)2
  • Primary hypercholesterolemia (LDL-C, 160-189 mg/dL; non-HDL-C, 190-219 mg/dL)*2
  • Metabolic syndrome - a total of 3 of the following is diagnostic2
    • Increased waist circumference (by ethnically appropriate cutpoints);
    • Elevated triglycerides (≥150 mg/dL, non-fasting)
    • Low HDL-C (< 50 mg/dL)
    • Elevated glucose
    • Elevated blood pressure
    • Chronic kidney disease (eGFR 15-59 mL/min/1.73 m2 with or without albuminuria; not treated with dialysis or kidney transplantation}2
    • High risk race or ethnicity (e.g. South Asian ancestry)2
    • Lipids and biomarkers (associated with increased ASCVD risk)2
      • Persistently elevated triglycerides (≥ 175 mg/dL, non-fasting)
      • Elevated high-sensitivity C-reactive protein (≥ 2.0 mg/L)
      • Elevated Lipoprotein(a) – ≥ 125 nmol/L constitutes risk-enhancing factor; relative indication for measurement is family history of premature ASCVD
      • Elevated Apolipoprotein B (≥ 130 mg/dL, corresponding to LDL-C > 160 mg/dL) constitutes risk-enhancing factor; relative indication for measurement is triglyceride ≥ 200 mg/dL (≥ 130 mg/dL)

Women with a medical history of pre-eclampsia who gave birth preterm (less than 37 0/7 weeks of gestation) or who have a medical history of recurrent preeclampsia, are recommended by ACOG to have a yearly assessment of blood pressure, lipids, fasting blood glucose, and body mass index.4

LabCorp offers a wide range of cardiovascular testing options.

For more information, please download the following brochure:

Lipid Cascade

Reference

  1. American Heart Association News. Most US women don’t know their personal risk for heart disease, poll finds. Available at https://news.heart.org/most-u-s-women-dont-know-their-personal-risk-for-...
  2. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease. Accessed August 12, 2019. Available at https://www.ahajournals.org/doi/suppl/10.1161/CIR.0000000000000678
  3. American Heart Association. AHA/ACOG Presidential Advisory. Promoting risk identification and reduction of cardiovascular disease in women through collaboration with obstetricians and gynecologists. Circulation. 2018;137:e1-e10
  4. American College of Obstetricians and Gynecologists. Well Women Recommendations. High-Risk Factors. Available at: https://www.acog.org/About-ACOG/ACOG-Departments/Annual-Womens-Health-Ca...